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Dr. Francesco Vanzi


Tuesday, October 18th, 2011 at 03:15:00 PM

Conference room Querzoli - LENS - via Nello Carrara 1 - Sesto Fiorentino (Florence)

Published on-line at 11:40:16 AM on Thursday, October 20th, 2011

Protein structural dynamics: from single molecule to living cells

LENS anniversary, biophysics area: how to investigate and manipulate proteins involved in the processes of movement of skeletal muscles.

In biophysics labs the researchers use single molecule techniques for the manipulation and detection of biological molecules in vitro and in vivo and imaging methodologies for analysis of biological structures and of various events in cells, tissues and living animals. Advanced applications of photonics tools are used to investigate morphological and spectroscopic properties of human tissues in vivo with a micron-scale resolution.

In movements of skeletal muscles are involved two proteins: myosin and actin within each muscle fiber. Tools such as second-harmonic generation (SHG) allow to reconstruct the atomic structures of proteins during processes and so highlight the molecular conformation of myosin during the muscle contraction. SHG provides so a method for label-free sub-micron resolution imaging in deep tissue, with intrinsic 3D sectioning capability.

[video=640 512]Ventesimo_pomeriggio_Francesco_Vanzi[/video]

This seminar took place during the celebrations for the LENS 20th anniversary to show to guests the biophysics research lines of laboratory. Video recordings by CSIAF.

For further informations, please contact Dr. Francesco Vanzi.