Molecular basis of neurodegenerative pathologies

This research line is devoted at applying advanced microscopy techniques and imaging approaches based on fluorescence to tackle the understanding, diagnosis and treatment of neurodegenerative diseases. We are currently focused on three main objectives:

1. Studying the molecular basis of Alzheimer’s disease, in particular the influence of cholesterol and neuronal activity on the processing of the amyloid precursor protein.

2. Investigating the release from nanoparticles and diffusion of drugs by means of single molecule tracking within the context of nose to brain delivery of biopharmaceutics to treat Multiple Sclerosis.

3. Translating basic research methods to the clinical diagnosis of infantile metabolic neurodegenerative diseases, such as GM1 Gangliosidosis.

Official web site: http://bio.lens.unifi.it/