Fundamental Science could play a key role in spurring Disruptive Innovation, shaping future possibilities in a responsible and sustainable way. Fundamental Research is carried out, by definition, with the aim to answer a question, to close a knowledge gap, without any requirement about applications. It implies investments with unpredictable or difficult-to-predict outcomes, exposing researchers to potential failure. Thus, to increase the chance to properly develop excellent new knowledge, scientists must feel free to be driven by their own curiosity during their research, with the awareness of the societal priorities and  mechanisms of value generation from knowledge. Independent science is a fundamental pillar of an enlightened democracy. We must protect this independency, and at the same time we must empower people to take full advantage of science independency and freedom, supporting the diffusion of scientific literacy on a larger scale/among society.
Carrying disruptive research means exploiting the potential of large scale international research infrastructures to broaden the frontiers of knowledge in fields like physics, chemistry, nanosciences, as well as capitalizing the disruptive power of new materials, which lies in boosting emerging technologies by shaping future devices with optimized functions. It is necessary to potentiate connections inside the innovation ecosystem, setting up more dialogue between scientists and investors as well as between scientists and policy makers. With this respect, greater flexibility and a smarter legal framework are needed to facilitate the quick scalability of innovative ideas. A stronger hybrid research and innovation ecosystem should be built to protect and support new start-ups and companies when they leave the protected scientific environment. The transition from the laboratory to the market is often very difficult due to the scarcity of fund and sometimes a complex and fragmentated regulatory framework.