• Research Area: Biophotonics
    In this research line we took advantage of three-photon fluorescence microscopy (3PFM) to extend the access to neuronal activity information at deeper structures of the brain.
  • Research Area: Biophotonics
    The use of light to stimulate and readout neuronal activity has several advantages, such as the noninvasiveness and the possibility to target with high spatial and temporal precision specific groups of neurons.
  • Research Area: Biophotonics
    We make use of multi-modal optical imaging techniques to perform the functional mapping of zebrafish larvae physiological and pathological brain activity. In particular, we adopt an acute epilepsy zebrafish model to investigate aberrant neuronal activity underlying seizure onset and propagation, a typical sign of this widespread neurological disorder.
  • Research Area: Biophotonics
    In this research line different imaging and spectroscopic methods are used to investigate the relation between morphology and molecular content in biological tissues, both in healthy and pathological condition in in-vivo and ex-vivo samples.
  • Research Area: Biophotonics
    The Cardiac Imaging research line is about innovative imaging methodologies to increase the understanding of cardiac physiology.
  • Research Area: Photonic Materials
    The Optics of Complex Systems group focuses its research on how complex media interact with light, but also on how light can be used to manufacture new materials and design their functionalities.
  • Research Area: Photonic Materials
    The investigation of the dynamical properties of condensed matter remains one of the major topic in the material science. The dynamics processes we study span from the vibrational and electronic phenomena, taking place at the microscopic scale, to the structural/aggregation and transport processes covering the macroscopic scale of the materials.
  • Research Area: Biophotonics
    This research line is dedicated to the development of experimental approaches for high-speed volumetric imaging and to their application to answer biologically relevant questions.
  • Research Area: Photonic Materials
    The research mainly concerns with the study of simple molecular systems under pressure, using the Diamond Anvil Cell (DAC) technique to compress the samples under equilibrium conditions up to 106 bar.
  • Research Area: Atomic Physics
    Cold atoms are the main ingredients of modern optical clocks, that can reach an accuracy of 10-18 seconds, against 10-15 s of atomic clocks. At LENS the research on optical clocks aims to simplify and reduce the size of the equipment to make them transportable, e.g. to send them in space. At lower temperatures, ultracold atoms in a condensed phase allow to perform atomic interferometry experiments and Strontium can be a useful quantum sensor to measure forces due to macroscopic source masses on micrometer distances, e.g. to investigate inverse-square Newton's law or Casimir effect.
  • Research Area: Photonic Materials
    This research activity focuses on the development and characterization of innovative semiconductors for applications to optoelectronic devices, photonics, photovoltaics, and sensors. Currently, the most part of the activities is focused on perovskites, a new class of materials with outstanding properties.
  • Research Area: Biophotonics
    We leverage the intrinsic optical sectioning, high contrast and direct fast 2D image recording of confocal light-sheet fluorescence microscopy (CLSFM) to obtain with cellular resolution three-dimensional reconstructions of large intact neuronal networks for an improved understanding of the mice and human brain structure.
  • Research Area: Biophotonics
  • Research Area: Biophotonics
    We are interested in how the brain processes and integrates information at the cortical level over multiple areas to produce behavioral responses and how these processes are altered in pathological conditions. To this end, we perform mesoscale functional imaging in awake mice expressing a fluorescent calcium indicator (GCaMP6f) in cortical excitatory neurons while animals are performing a behavioral task.
  • Research Area: Biophotonics
    The Molecular and Cellular Mechanobiology research line is focused on the mechanisms underlying mechanical regulation of biological systems.
  • Research Area: Biophotonics
    This research line is devoted at applying advanced microscopy techniques and imaging approaches based on fluorescence to tackle the understanding, diagnosis and treatment of neurodegenerative diseases.
  • Research Area: Photonic Materials
    Light matter interaction at the nanoscale occurs in novel ways. Understanding these interactions is not only of fundamental importance but is also of interest for applications in optical sensing, optoelectronics, high performance integrated optics and quantum science. Our group investigates innovative light emitter and their integration in photonic structures capable to manipulate and confine light at the nanoscale.
  • Research Area: Biophotonics
    Nanosensing research line aims at developing novel multifunctional optical sensors enabling for smart applications in chemical and biological sensing through the molecular screening of samples with improved sensitivity towards selective analytes.
  • Research Area: Biophotonics
    Our main focus is currently the dissection of brain circuits involved in the formation and consolidation of fear memory.
  • Research Area: Atomic Physics
    Ultracold atoms trapped in optical lattices can be the material base for two kind of calculator: quantum computers and quantum simulators. In the first case, today's challenge at LENS concerns the ability to implement qubits, the basic elements of quantum information, on spin and/or electronic states of cold atoms (e.g. Itterbium) and to manipulate them one by one to perform calculations. In the second case, cold atoms in a optical lattices can show an electron-like behavior and allow an indirect study of conduction phenomena in condensed matter physics, such as superconductivity, Anderson localization, graphene properties and much more, thanks to the ability to draw very specific configurations of the lattices.
  • Research Area: Atomic Physics
    Interactions between atoms can be tuned by using static magnetic fields in proximity of so-called Feshbach resonances. The set of physical phenomena that can be studied by tuning intra- and inter-species interactions of atoms and mixtures in optical lattices is very large and ranges from the production of ultracold polar molecules to the engineering of novel quantum states of matter. The short-ranged isotropic interaction between atoms is indeed at the basis of superfluidity in Bose and Fermi systems, quantum phases in periodic and disordered potentials, entanglement. On the other hand, in a quantum gas of polar molecules a strong, tunable, long-range, anisotropic interaction appears, adding new ingredients to the study of superfluidity, quantum phase transitions, lattice models and quantum computation. Mixtures of different atoms that follow the two quantum statistics are also interesting to study a series of fundamental phenomena, ranging from condensed-matter to molecular physics.
  • Research Area: Biophotonics
    Slow-wave oscillatory activity is critical for several fundamental processes from general brain homeostasis to memory consolidation. Further, there is increasing evidence in support of SW activity alterations in different brain diseases. In this project, the long-term goal is to correlate the delicate equilibrium between excitatory and inhibitory neurons, mirrored into patterns of propagating waves, and large-scale functional connectivity in different brain states (awake, anesthetized, natural sleep).
  • Research Area: Atomic Physics
    Laser spectroscopy of cold molecules is a powerful tool to address fundamental physical questions. We develop new methods to cool and control neutral molecules and apply them to improve the resolution of the spectroscopic measurements. We develop novel narrow-linewidth light sources in the mid IR which are absolutely referenced to the primary frequency standard via a fibre-link to the National Metrological Institute in Torino, INRIM.
  • Research Area: Biophotonics
    Super-resolution fluorescence microscopy techniques have become increasingly popular over the last decade, owing to the fact that they allow investigators to resolve details orders of magnitude smaller than the optical resolution limit, without having to resort to methods such as electron or scanning probe microscopy techniques.
  • Research Area: Biophotonics
    The Tissue Biomechanics research targets the morphology, composition and biomechanics of biological tissues, trying to correlate the molecular and ultrastructural behavior with the properties observed at a macroscopic level.
  • Research Area: Biophotonics
    We exploit the high-resolution and penetration depth achievable with Two-Photon Fluorescence Microscopy (TPFM) to perform both structural and functional analysis on different animal models, and mesoscopic reconstruction of human brain tissue.